OPTIMIZING HEALTH WITH JARDIANCE

Jardiance is a medication used to treat type 2 diabetes. Its generic name is empagliflozin. It belongs to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors. Jardiance works by helping the kidneys get rid of glucose from your bloodstream through urine. This helps lower blood sugar levels in people with diabetes.

How Jardiance Works

Empagliflozin, the active ingredient in Jardiance, works by inhibiting SGLT2, a protein responsible for reabsorbing glucose in the kidneys. By blocking this protein, Jardiance promotes the excretion of excess glucose in the urine, thereby lowering blood sugar levels in individuals with type 2 diabetes.

Indications for Use

Jardiance is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also approved to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease.

Dosage and Administration

The typical starting dose of Jardiance is 10 mg once daily, taken in the morning, with or without food. The dosage may be increased to 25 mg once daily if tolerated. It can be taken with or without food.

Side Effects

Common side effects of Jardiance may include urinary tract infections, genital yeast infections, increased urination, and dehydration. More serious side effects can include ketoacidosis, kidney problems, low blood sugar when used with insulin or sulfonylureas, and serious urinary tract infections.

Contraindications

Jardiance is contraindicated in patients with a history of serious hypersensitivity reactions to empagliflozin and in patients with severe renal impairment (eGFR less than 30 mL/min/1.73 m²).

Precautions

Patients taking Jardiance should be monitored for signs and symptoms of ketoacidosis, acute kidney injury, hypotension, and necrotizing fasciitis of the perineum (Fournier’s gangrene). It should be used cautiously in patients at risk for volume depletion or hypotension.

Pregnancy and Lactation

There are no adequate and well-controlled studies of Jardiance in pregnant women. It is not recommended during the second and third trimesters of pregnancy. It is also not known whether empagliflozin is excreted in human milk.

Interactions

Jardiance may interact with other medications such as diuretics, insulin or insulin secretagogues, rifampin, and digoxin. It is important to consult a healthcare professional regarding potential drug interactions before starting Jardiance.

Conclusion

In conclusion, Jardiance (empagliflozin) is a medication used to treat type 2 diabetes by helping the kidneys eliminate excess glucose from the body through urine. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease.