PYODERMA GAGRENOSUM IS MOST COMMONLY ASSOCIATED WITH

• A. Ulcerative colitis ✓
• B. Crohn’s disease
• C. Amoebic colitis
• D. Ischaemic colitis

Pyoderma gangrenosum is a rare, inflammatory skin disorder characterized by painful ulcers that typically begin as small papules or nodules and rapidly progress to large, necrotic ulcers with undermined borders. The condition is often associated with underlying systemic diseases, most commonly inflammatory bowel disease (IBD), particularly ulcerative colitis. In fact, up to 50% of patients with pyoderma gangrenosum have an underlying IBD, with ulcerative colitis being the most frequently linked subtype.

Ulcerative colitis is a chronic inflammatory condition that primarily affects the colon and rectum, leading to symptoms such as abdominal pain, diarrhea, and rectal bleeding. The association between pyoderma gangrenosum and ulcerative colitis is well-documented in medical literature, with studies suggesting a strong correlation between the two conditions. While the exact pathogenesis of this association remains unclear, it is believed to involve dysregulation of the immune system and abnormal inflammatory responses.